PDF Reducing the metabolic burden of rRNA synthesis promotes healthy
with prerRNA processing and synthesis of ribosomal proteins consumes a large portion of the cellular biosynthetic and energetic capacity45Moreover ribosome biogenesis is required for mRNA
Small nucleoli are a cellular hallmark of longevity Nature
Reducing the metabolic burden of rRNA synthesis promotes healthy
Conversely the enhancement of prerRNA synthesis boosts growth and neuromuscular performance of young nematodes at the cost of accelerated metabolic decline mitochondrial stress and premature aging
Reducing the metabolic burden of rRNA synthesis promotes healthy
Our genetic analysis reveals that mutants that reduce protein synthesis namely rsks1 ife2 and Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis
Reducing the metabolic burden of rRNA synthesis promotes healthy
Reducing The Metabolic Burden Of Rrna Synthesis Promotes
Reducing the metabolic burden of rRNA synthesis promotes healthy
Reducing the metabolic burden of rRNA synthesis promotes healthy
Reducing the metabolic burden of rRNA synthesis promotes healthy
Ribosome biogenesis is initiated by RNA polymerase I Pol Imediated synthesis of preribosomal RNA prerRNA Pol I activity was previously linked to longevity but the underlying mechanisms
Reducing the metabolic burden of rRNA synthesis promotes healthy
Limiting Pol I activity extends lifespan more potently than direct repression of protein synthesis and confers geroprotection even when initiated late in life showcasing this intervention as an effective longevity and metabolic health treatment not limited by aging Ribosome biogenesis is initiated by RNA polymerase I Pol Imediated synthesis of preribosomal RNA prerRNA Pol I activity
Reducing The Metabolic Burden Of Rrna Synthesis Promotes
Our indepth analyses demonstrated that curtailment of prerRNA synthesis attenuates metabolic aging and stabilizes energy turnover providing an ATP surplus for healthy homeostasis Importantly we found a similar energy preservation effect upon depletion of the ribosomal protein RPS15 previously linked to life span extension in C elegans 30
Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans Samim Sharifi Prerana Chaudhari Asya Martirosyan Alexander Otto Eberhardt Finja Witt André Gollowitzer Lisa Lange Yvonne Woitzat Eberechukwu Maryann Okoli Huahui Li Norman Rahnis Joanna Kirkpatrick Oliver Werz Alessandro Ori Andreas Koeberle Holger Bierhoff and Maria Ermolaeva
Ribosome biogenesis is initiated by RNA polymerase I Pol Imediated synthesis of preribosomal RNA prerRNA Pol I activity was previously linked to longevity but the underlying mechanisms were not studied beyond effects on nucleolar structure and protein translation Here we use multiomics and functional tests to show that curtailment of Pol I activity remodels the lipidome and
Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans Reduced prerRNA synthesis improves energy homeostasis and metabolic plasticity also in human primary cells Conversely the enhancement of prerRNA synthesis boosts growth and neuromuscular performance of young nematodes at the cost of
Reducing the metabolic burden of rRNA synthesis promotes healthy
AbstractRibosome biogenesis is initiated by RNA polymerase I Pol Imediated synthesis of preribosomal RNA prerRNA Pol I activity was previously linked to longevity but the underlying mechanisms were not studied beyond effects on nucleolar structure and protein translation Here we use multiomics and functional tests to show that curtailment of Pol I activity remodels the lipidome and